高 峰（教授，博士生导师）

研究生招生专业：化学、药学、生物与医药

地址：云南大学呈贡校区自然资源药物化学教育部重点实验室1201

电子信箱：gaofeng@ynu.edu.cn

  教育工作经历：

南开大学化学系学士、硕士。中山大学化学与化学工程学院博士。中山大学化学与化学工程学院讲师。教育部国家公派留学博士后（美国佐治亚理工学院）。人社部香江学者博士后（香港科技大学）。云南大学化学科学与工程学院/自然资源药物化学教育部重点实验室/药学院副教授、教授。

研究领域：

1、荧光/磷光过渡金属配合物用于抗肿瘤光动力、声动力、光热、化疗等多机制协同治疗和成像。

2、艾滋病毒TAR RNA识别及抗艾滋病毒逆转录酶活性及机理。

3、基于量子化学理论计算的化合物结构、光物理性质、光化学性质及生物活性的关系。

科研项目：

1、国家自然科学基金，单分子光声热多重成像引导和激活的多模式协同抗肿瘤诊疗一体化平台，2025年01月至2028年12月，主持。

2、国家自然科学基金，多核异核钌锇配合物抗肿瘤活性及机理研究，2022年01月至2025年12月，主持。

3、云南省重点项目，金属配合物作为黑色素瘤和非小细胞肺癌耐药瘤的光动力/光热/光激活化疗试剂的设计及药学研究，2024年03月至2027年02月，主持。

4、首批云南省万人计划青年拔尖人才（现“兴滇英才支持计划”），2018年。

5、国家自然科学基金，具有艾滋病毒逆转录酶抑制活性的荧光金属配合物的合成及机理研究，2017年01月至2020年12月，主持。

6、云南省面上项目，卟啉作为TAR RNA荧光探针及其HIV逆转录酶抑制研究，2018年06月至2021年05月，主持。

7、作为项目负责人和主要参加人已完成其他国家自然科学基金面上项目、青年基金、教育部创新团队、教育部985高校青年教师培育项目、973子课题、863子课题、云南大学引进人才项目等十余项。

论文（近三年）：

[1] Ran Song, Run-Yu Zhao, Ru Yan, Xue-Lian Li, Li-Zhen Zeng, Zhongyan Cai, Jingbo Chen*, Xiaoxia Ren*, Xiaohong Cheng*, Feng Gao*, Nonemissive Ruthenium Complexes for Near Infrared-II Photodynamic, Photothermal, Sonodynamic, and Sonothermal Therapy Against Drug-Resistant Cancer, Journal of Medicinal Chemistry, 2025, 68, 17653-17666.

[2] Xiao-Xia Ren, Xue-Lian Li, Run-Yu Zhao, Yun Li, Ran Song, Meng-Chi Han, Yu-Fei Yan, Li-Zhen Zeng, Zhong-Yan Cai, Feng Gao*, Dinuclear Ru(II) Complexes for Synergetic Photodynamic, Photothermal, and Sonodynamic Therapy against Cisplatin-Resistant Cancer, Inorganic Chemistry, 2025, 64, 9596-9607.

[3] Li-Zhen Zeng, Xue-Lian Li, Yu-Ang Deng, Run-Yu Zhao, Ran Song, Yu-Fei Yan, Meng-Fan Wang, Xiang-Han Wang, Xiaoxia Ren*, Feng Gao*, Dinuclear Dicationic Iridium Complexes for Highly Synergistic Photodynamic and Photothermal Therapy to Chemo-Resistant Cancer, Inorganic Chemistry, 2025, 64, 967-977.

[4] Yu-Fei Yan, Xue-Lian Li, Li-Zhen Zeng, Qishuai Liu, Zhongyan Cai, Yanrong Ren, Xiaoxia Ren*, Feng Gao*, Antitumor Cream: Transdermal Hydrogel Containing Liposome-Encapsulated Ruthenium Complex for Infrared-Controlled Multimodal Synergistic Therapy, Advanced Healthcare Materials, 2025, 14, 2403563.

[5] Dan-Dan Xie, Xue-Lian Li, Li-Zhen Zeng, Xiaoxia Ren, Dan Zhang, Rong Yang*, Feng Gao*, Substituent-Modulated Excited Triplet States and Activities of Ruthenium Complexes for Dual Photodynamic/Sonodynamic Therapy to Cisplatin-Resistant Non-Small Cell Lung Cancer, ChemBioChem, 2025, 26, e202400801. (Invited Paper)

[6] Xue-Lian Li, Meng-Fan Wang, Li-Zhen Zeng, Guo-Kui Li, Run-Yu Zhao, Fu-Dan Liu, Yun Li, Yu-Fei Yan, Qishuai Liu, Zhao Li, Hongbin Zhang, Xiaoxia Ren*, Feng Gao*, Bithiophene-Functionalized Infrared Two-Photon Absorption Metal Complexes as Single-Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy, Angewandte Chemie International Edition, 2024, 63, e202402028.

[7] Dan-Dan Xie, Ran Song, Xiaohong Cheng, Hongbin Zhang, Yuan-Fang Wei*, Feng Gao*, From Intercalation to External Binding: Ru(II) Complexes with a Spiro Ligand for TAR RNA Selective Binding and HIV-1 Reverse Transcriptase Inhibition, Inorganic Chemistry, 2024, 63, 12342-12349.

[8] Meng Liu, Dan-Dan Xie, Yuan-Xiao Guo, Run-Yu Zhao, Fu-Dan Liu, Hongbin Zhang, Feng Gao*, TAR RNA selective targeting ruthenium(II) complexes as HIV-1 reverse transcriptase inhibitors: On exploring structure-activity relationships of multiple positions, Journal of Inorganic Biochemistry, 2024, 259, 112664.

[9] Xue-Lian Li, Li-Zhen Zeng, Rong Yang, Xu-Dan Bi, Yang Zhang, Ruo-Bing Cui, Xin-Xi Wu, Feng Gao*, Iridium(III)-Based Infrared Two-Photon Photosensitizers: Systematic Regulation of Their Photodynamic Therapy Efficacy, Inorganic Chemistry, 2023, 62, 16122-16130.

[10] Shi-Jie Tang, Qing-Fang Li, Meng-Fan Wang, Rong Yang, Li-Zhen Zeng, Xue-Lian Li, Rui-Dong Wang, Hongbin Zhang, Xiaoxia Ren, Dan Zhang, Feng Gao*, Bleeding the Excited State Energy to the Utmost: Single-Molecule Iridium Complexes for In Vivo Dual Photodynamic and Photothermal Therapy by an Infrared Low-Power Laser, Advanced Healthcare Materials, 2023, 12, 2301227.

[11] Yu-Ang Deng, Shi-Jie Tang, Meng-Fan Wang, Xiaoxia Ren, Xue-Lian Li, Li-Zhen Zeng, Dan-Ni Ren, Meng-Ru Wang, Wei-Lie Xiao, Zhong-Yan Cai, Dan Zhang, Hongbin Zhang, Feng Gao*, Heterometallic ruthenium-osmium complexes: dual photodynamic and photothermal therapy for melanoma and drug-resistant lung tumor in vivo, Inorganic Chemistry Frontiers, 2023, 10, 4552-4561.

[12] Shi-Jie Tang, Meng-Fan Wang, Rong Yang, Meng Liu, Qing-Fang Li, Feng Gao*, More-Is-Better Strategy for Constructing Homoligand Polypyridyl Ruthenium Complexes as Photosensitizers for Infrared Two-Photon Photodynamic Therapy, Inorganic Chemistry, 2023, 62, 8210-8218.

[13] Meng-Fan Wang, Rong Yang, Shi-Jie Tang, Yu-Ang Deng, Guo-Kui Li, Dan Zhang, Daomei Chen, Xiaoxia Ren, Feng Gao*, In vivo Realization of Dual Photodynamic and Photothermal Therapy for Melanoma by Mitochondria Targeting Dinuclear Ruthenium Complexes under Civil Infrared Low-power Laser, Angewandte Chemie International Edition, 2022, 61, e202208721.

[14] Meng-Fan Wang, Yu-Ang Deng, Qing-Fang Li, Shi-Jie Tang, Rong Yang, Xiaoxia Ren, Dan Zhang, Feng Gao*, Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents in vivo. Chemical Communications, 2022, 58, 12676-12679.

[15] Rong Yang, Xu-Dan Bi, Yan Li, Meng Liu, Man-Qi Hu, Li-Min Zhao, Hongbin Zhang, Feng Gao*, Scorpion-Shaped Zinc Porphyrins as Tetrafunctional TAR RNA Predators and HIV-1 Reverse Transcriptase Inhibitors, Inorganic Chemistry, 2022, 61, 10774-10780.

[16] Meng-Fan Wang, Yan Li, Xu-Dan Bi, Yuan-Xiao Guo, Meng Liu, Hongbin Zhang, Feng Gao*, Polypyridyl ruthenium complexes as bifunctional TAR RNA binders and HIV-1 reverse transcriptase inhibitors, Journal of Inorganic Biochemistry, 2022, 234, 111880.

[17] Yuan-Xiao Guo, Meng Liu, Yu-Qiong Zhou, Xu-Dan Bi, Feng Gao*, Terpyridyl ruthenium complexes as visible spectral probe for poly(A) RNA and bifunctional TAR RNA binders and HIV-1 reverse transcriptase inhibitors, Inorganica Chimica Acta, 2022, 539, 121027.

发明专利：

[1] 第一发明人授权美国发明专利METALLOPORPHYRIN COMPOUND, AND PREPARATION AND USES THEREOF, 2021, US 11,168,096 B2。

[2] 以第一发明人申请中国发明专利17项，授权13项，实审中4项。

荣誉和近期学术活动：

广东省科学技术奖自然科学类一等奖（2011）

中国化学会第十三届全国化学生物学学术会议（2025），口头报告

中国化学会第九届全国卟啉、酞菁及相关材料学术研讨会暨第三届亚洲卟啉、酞菁及相关材料学术会议（2025），邀请报告

5th Int'l Conference on Medicinal Chemistry and Drug Discovery（2025），Keynote Speech，Session Chair