赵立兴
邮箱：lixingzhao@ynu.edu.cn
职称：研究员
地址：云南大学呈贡校区药学院，国家重点实验室1栋1420
教育经历
1997.08-2000.06，中国科学院沈阳应用生态研究所，微生物学，理学博士
1994.09-1997.07，中国林业科学研究院，植物学，理学硕士
1990.09-1994.07，安徽农学院，林学，农学学士
工作经历
2023.04-至今， 云南大学，药学院，教育部自然资源药物化学重点实验室，云南省微生物研究所，研究员
2018.11-2023.04，云南大学，教育部自然资源药物化学重点实验室、云南省微生物研究所，研究员
2012.11-2018.11，云南大学，云南省微生物研究所， 副研究员
2007.05-2012.11，云南大学，云南省微生物研究所，助理研究员
2007.08-2008.07，美国威斯康星州麦迪逊大学，药学院，访问学者
2000.06-2007.05，昆明制药集团股份公司，药物研究院，工程师
研究领域
1) 微生物天然药物研究：微生物是临床使用的抗感染、抗肿瘤等药物的重要来源，在农畜牧业生产中也广泛；从各种环境下收集到的活性菌株中发现微生物天然药物分子或先导化合物，进行微生物天然药物的研究与开发。
2) 微生物资源及其综合利用：微生物在各种环境下广泛存在，开展纯培养微生物的资源收集与整理，生物功能筛选并加以利用。
奖励荣誉和学术任职
云南省科学技术进步奖二等奖“三七种植土壤障碍因素消减关键技术体系的建立与应用”，2018
云南省自然科学奖一等奖“放线菌系统学研究”，2008
云南大学“中青年骨干教师”培养计划，2013
执教课程与教学成果
主讲《微生物药物学概论》，《微生物学概论》，《微生物·自然界的万能者》
科研项目
1) 云南省科技厅-云南大学联合专项重点项目，抗耐多药病原菌的放线菌功能基因与活性化合物的挖掘， 2022.01-2024.12，主持
2) 国家自然科学基金地区项目，三株稀有放线菌中抗耐药病原菌的活性新化合物挖掘， 2022.01-2025.12，主持
3) 国家自然科学基金地区项目，三七活性成分诱导下的三七内生菌新颖活性代谢产物及其功能研究， 2018.01-2021.12，主持
4) 国家自然科学基金地区项目，拮抗三七根腐病病原真菌的放线菌代谢产物及其作用机制， 2016.01-2019.12，主持
5) 国家自然科学基金地区项目，嗜盐放线菌新物种抗肿瘤活性代谢产物研究， 2011.01-2013.12，主持
代表性论文
1) Xu, Y. #; Hu, B.-Y.#; Qin, Y.; Zhuang, L.; Yang, Y.-B.*; Zhao, L.-X.*, Jiangchuanmycin, a new pyrrolizidine analog from Streptomyces sp. YIM S01863. Chemistry & Biodiversity 2023, Article; Early Access. DOI: 10.1002/cbdv.202201240. (IF = 2.745)
2) Qian, M.-A.#; Yang, Y.-B.#; Hu, B.-Y.; Xu, Y.; Wang, Z.-H.; Li, Q.-Y.; Gao, Y.-H.; Luo, X.-D.*; Zhao, L.-X.*, Baoshanmycin and a new furanone derivative from a soil-derived actinomycete, Amycolatopsis sp. YNNP 00208. Chemistry & Biodiversity 2022, 19(5), e202200064. DOI: 10.1002/cbdv. 202200064. (IF = 2.745)
3) Hu, B.-Y#; Yang, Y.-B.#; Xiong, D.-S.; He, Y.-J.; Zhou, Z.-S.; Zhu, P.-F.; Wang, Z.-J.; Zhao, L.-X.*, Luo, X.-D.*, Potent antihyperuricemic triterpenoids based on two unprecedented scaffolds from the leaves of Alstonia scholaris. Orgainic Letters 2021, 23(11), 4158-4162. DOI: 10.1021/acs.orglett.1c01102. (IF = 6.072)
4) Wang, Y.-L.#; Hu, B.-Y. #; Qiang, M.-A.; Wang, Z.-H.; Zou, J.-M.; Sang, S.-Y.; Li, L.; Luo, X.-D.*; Zhao, L.-X.*, Koninginin W, a new polyketide from the endophytic fungus Trichoderma koningiopsis YIM PH30002. Chemistry & Biodiversity 2021, 18(9), e2100460. DOI: 10.1002/cbdv.202100460. (IF = 2.745)
5) Xiong, D.S.#; Yang, Y.-B.#; Hu, B.-Y.; Miao, C.-P.; Wang, Y.-L.; Zou, J.-M.; Li, L.; Li, Y.-Q.; Luo, X.-D.*; Zhao, L.-X.*, Myrothins A-F from endophytic fungus Myrothecium sp. BS-31 harbored in Panax notoginseng. Chemistry & Biodiversity 2021, 18(3), e202000964. DOI: 10.1002/cbdv.202000964. (IF = 2.745)
6) Hu, J.-Y.#; Li, L.; Peng, G.; Li, Y.-Q.; Xu, L.-H.; Guan, H.-L.; Zhao, L.-X.*; Miao, C.-P.*, Nocardia panacis sp. nov., a novel actinomycete with antihyphytopathogen activity isolated from the rhizosphere of Panax notoginseng. Antomie van Leeuwenhoek 2020, 113(2), 165-174. DOI: 10.1007/s10482-019-01326-z. (IF = 2.158)
7) Peng, G.#; Xiong, D.-S.#; Li, L.-C.; Hu, J.-Y.; Bao, S.; Chen, Y.-W.; Li, Y.-Q.; Xu, L.-H.; Miao, C.-P.*; Zhao, L.-X.*, Amycolatopsis panacis sp. nov., isolated from Panax notoginseng rhizospheric soil. International Journal of Systematic and Evolutionary Microbiology 2019, 69(2), 567-571. DOI: 10.1099/ijsem.0.003202. (IF = 2.689)
8) Luo, N.#; Yang, Y.-B.#; Yang, X.-Q.; Miao, C.-P.; Li, Y.-Q.; Xu, L.-H.; Ding, Z.-T.*; Zhao, L.-X.*, The streptazolin- and obscurelide-type metabolites from soil-derived Streptomyces alboniger YIM20533 and the mechanism of influence of -butyrolactone on the growth of Streptomyce by their non-enzymatic reaction biosynthesis. RSC Advances 2018, 8(61), 35042-35049. DOI: 10.1039/c8ra06690f. (IF = 3.789)
9) Wang, Q.#; Yang, Y.-B.#; Yang, X.-Q.; Miao, C.-P.; Li, Y.-Q.; Liu, S.-X.; Luo, N.; Ding, Z.-T.*; Zhao, L.-X.*, Lovastatin analogues and other metabolites from soil-derived Aspergillus terreus YIM PH30711. Phytochemistry 2018, 145, 146-152. DOI: 10.1016/phytochem.2017.11.006. (IF = 4.004)
10) Zheng, Y.-K.#; Miao, C.-P.#; Chen, H.-H.; Huang, F.-F.; Xia, Y.-M.; Chen, Y.-W.; Zhao, L.-X.*, Endophytic fungi harbored in Panax notoginseng: diversity and potential as biological control agents against host plant pathogens of root-rot disease. Journal of Ginseng Research 2017, 41(3), 353-360. DOI: 10.1016/j.jgr.2016.07.005 (IF = 5.735)
11) Chen, J.-L.#; Sun, S.-Z.#; Miao, C.-P.; Wu, K.; Chen, Y.-W.; Xu, L.-H.; Guan, H.-L.*; Zhao, L.-X.*, Endophytic Trichoderma gamsii YIM PH30019: a promising biocontrol agent with hyperosmolar, mycoparasitism, and antagonistic activities of induced volatile organic compounds on root-rot pathogenic fungi of Panax notoginseng. Journal of Ginseng Research 2016, 40(4), 315-324. DOI: 10.1016/j.jgr.2015.09.006 (IF = 5.735)
12) Fan, Z.-Y.#; Miao, C.-P.#; Qiao, X.-G.; Zheng, Y.-K.; Chen, H.-H.; Chen, Y.-W.; Xu, L.-H.; Zhao, L.-X.*; Guan, H.-L.*, Diversity, distribution, and antagonistic activities of rhizobacteria of Panax notoginseng. Journal of Ginseng Research 2016, 40(2), 97-104. DOI: 10.1016/j.jgr.2015.05.003 (IF = 5.735)
13) Miao, C.-P.#; Mi, Q.-L.#; Qiao, X.-G.; Zheng, Y.-K.; Chen, Y.-W.; Xu, L.-H.; Guan, H.-L.*; Zhao, L.-X.*, Rhizospheric fungi of Panax notoginseng: diversity and antagonism to host phytopathgoens. Journal of Ginseng Research 2016, 40(2), 127-134. DOI: 10.1016/j.jgr.2015.06.004 (IF = 5.735)
14) Liu, K.#; Yang, Y.-B.#; Miao, C.-P.; Zheng Y.-K.; Chen, J.-L.; Chen, Y.-W.; Xu, L.-H.; Guan, H.-L.; Ding, Z.-T.*; Zhao, L.-X.*, Koningiopisins A-H, polyketides with synergistic antifungal activities from the endophytic fungus Trichoderma koningiopsis. Planta Medica 2016, 82(4): 371-376. DOI: 10.1055/s-0035-1558228 (IF = 3.007)
15) Xiong, Z.-J.#; Miao, C.-P.#; Zheng, Y.-K.; Liu, K.; Li, W.-J.; Liu, W.-H.; Xu, L.-H.; Zhao, L.-X.*, Stackebrandtia endophytic sp. nov., an actinobacterium isolated from Tripterygium wilfordii. International Journal of Systematic and Evolutionary Microbiology 2015, 65, 1709-1713. DOI: 10.1099/ijs.0.000166 (IF = 2.689)
16) Cao, P.#; Yang, J.#; Miao, C.-P.; Yan, Y; Ma, Y.-T.; Li, X.-N.; Zhao, L.-X.*; Huang, S.-X.* New duclauxamide from Penicillium manginii YIM PH30375 and structure revision of the duclauxin family. Organic Lettters 2015, 17(5), 1146-1149. (IF = 6.072)
