夏成峰
邮箱：xiacf@ynu.edu.cn
职称：教授（博士生导师）
地址：云南大学呈贡校区药学院，国重楼1栋1224
教育经历
1997.09-2002.07，中国科学院上海有机化学研究所，有机化学，理学博士
1992.09-1997.07，北京大学化学与分子工程学院，化学，理学学士
工作经历
2023.04-至今， 云南大学，药学院，教授
2015.12-2023.04，云南大学，教育部自然资源药物化学重点实验室，教授
2009.08-2015.11，中国科学院昆明植物研究所，研究员
2004.10-2009.07，美国俄亥俄州立大学，化学与生物化学系，博士后
研究领域
1) 可见光反应：发展新型可见光催化剂，通过可见光照射将电子跃迁到高能激发态并发生电子转移反应，开展化学新反应的研究。
2) 天然产物和药物分子合成：采用课题组发展的合成方法学，对具有重要生理活性的天然产物和药物分子开展全合成研究，并通过构效关系研究为天然产物的药物研究和其它功能研究提供基础。
奖励荣誉和学术任职
云南省“兴滇英才支持计划”第一层次“云岭学者”，2022
云南省“百名海外高层次人才引进计划”，2011
云南省“高端科技人才引进计划”，2010
中国科学院“百人计划”，2009
执教课程与教学成果
主讲《有机化学》
主持2019年云南省博士生导师团队
科研项目
1) 云南省“云岭学者”项目，芳基氘代药物研究，2023.01-2027.12，主持。
2) 国家自然科学基金面上项目，基于不对称可见光环化反应的C-17羟基酯类吲哚生物碱合成，2023.01-2026.12，主持。
3) 国家自然科学基金面上项目，Akuammiline生物碱的全合成研究，2019.01-2022.12，主持。
4) 云南省科技厅重点项目，可见光反应在天然产物研究中的应用，2018.09-2021.08，主持。
5) 国家自然科学基金面上项目，蕊木碱类吲哚生物碱的集群合成，2016.01-2019.12，主持。
6) 国家自然科学基金面上项目，抗肿瘤吲哚生物碱melotenine A的合成和构效关系研究，2013.01-2016.12，主持。
7) 云南省科技厅重点项目，蘑菇中自然杀伤T细胞新抗原的作用机制和构效关系研究，2014.10-2017.09，主持。
8) 云南省高端科技人才引进计划，T细胞免疫药物的研究，2011.01-2015.12，主持。
9) 云南省海外百人计划，自然杀伤T细胞抗原的研究，2012.01-2015.12，主持。
10) 国家重点基础研究发展计划（973计划），重要生理功能和重大疾病相关蛋白质及配体分子公共资源库建设，2011.08-2015.07，参加。
11) 中国科学院“百人计划”专项基金，天然产物合成和活性研究，2011.08-2014.08，主持。
近五年代表性论文
1) Yuxi Gao, Lijuan Gao, Endiao Zhu, Yunhong Yang, Mi Jie, Jiaqian Zhang, Zhiqiang Pan*, Chengfeng Xia* “Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes” Nature Communications, 2023, 14, 7917.
2) Linlin Zhang, Fengchi Hu, Lei Shen, Lijuan Gao, Yunhong Yang, Zhiqiang Pan,* Chengfeng Xia* “Redox-Neutral Intramolecular Dearomative Spirocyclization of Phenols Induced by Visible Light” Organic Letters, 2023, 25, 3168−3172.
3) Kangjiang Liang,# Xipan Li,# Delian Wei, Cuihua Jin, Chuanwang Liu, Chengfeng Xia* “Deprotection of benzyl-derived groups via photochemically mesolytic cleavage of C–N and C–O bonds” Chem, 2023, 9, 511-522.
4) Dongyan Hu, Yang Zhang, Jianwei Li, Kangjiang Liang,* Chengfeng Xia* “Water-mediated radical C-H tosylation of alkenes with tosyl cyanide” Chemical Communications, 2023, 59, 462-465.
5) Yuzhen Ding, Lei Shen, Kangjiang Liang, Chengfeng Xia* “Synthesis of C2-Carbonyl Indoles via Visible Light-Induced Oxidative Cleavage of an Aminomethylene Group” Journal of Organic Chemistry, 2022, 87, 16644-16654.
6) LinLin Ren, Yonggong Wang, Yanman Huo, Xiaogang Tong,* Chengfeng Xia* “Direct synthesis of C3-alkynyl pyrroloindolines from tryptamines via a visible-light-induced radical cascade reaction” Chemical Communications, 2022, 58, 13935-13938.
7) Qinglong Liu,# Yuzhen Ding,# Yuxi Gao, Yunhong Yang, Lijuan Gao, Zhiqiang Pan,* Chengfeng Xia* “Decatungstate Catalyzed Photochemical Acetylation of C(sp3)−H Bonds” Organic Letters, 2022, 24, 7983−7987.
8) Jiaying Tang, Linlin Ren, Jianwei Li, Yonggong Wang, Dongyan Hu, Xiaogang Tong,* Chengfeng Xia* “Photochemical Synthesis of Indolocarbazoles through Tandem Indolization/Dimerization/Mannich Cyclization from Allenes” Organic Letters, 2022, 24, 3582-3587.
9) Wenbin Shang, Fengyuan Peng, Qianlang Feng, Fei Fang, Zhiqiang Pan, Xu Ji,* Chengfeng Xia* “Nitrogen-centered radical-mediated α-sulfonimidation of ketones” Organic Chemistry Frontiers, 2022, 9, 2680-2684.
10) Zhixian Ma, Ankun Zhou, Chengfeng Xia* “Strategies for total synthesis of bispyrrolidinoindoline alkaloids” Natural Product Reports, 2022, 39, 1015-1044
11) Tao Li, Kangjiang Liang, Jiaying Tang, Yuzhen Ding, Xiaogang Tong, Chengfeng Xia* “A photoexcited halogen-bonded EDA complex of the thiophenolate anion with iodobenzene for C(sp3)–H activation and thiolation” Chemical Science, 2021, 12, 15655–15661.
12) Delian Wei, Xipan Li, Lei Shen, Yuzhen Ding, Kangjiang Liang,* Chengfeng Xia* “Phenolate anion-catalyzed direct activation of inert alkyl chlorides driven by visible light” Organic Chemistry Frontiers, 2021, 8, 6364–6370.
13) Yang Zhang, Dan Ye, Lei Shen, Kangjiang Liang, Chengfeng Xia* “Tandem Photoredox-Chiral Phosphoric Acid Catalyzed Radical−Radical Cross-Coupling for Enantioselective Synthesis of 3‑Hydroxyoxindoles” Organic Letters, 2021, 23, 7112−7117.
14) Haiyang Wang, Tao Li, Dongyan Hu, Xiaogang Tong, Liyan Zheng, Chengfeng Xia* “Acylation of Arenes with Aldehydes through Dual C−H Activations by Merging Photocatalysis and Palladium Catalysis” Organic Letters, 2021, 23, 3772−3776.
15) Wenbin Shang, Chunyu Zhu, Fengyuan Peng, Zhiqiang Pan, Yuzhen Ding, Chengfeng Xia* “Nitrogen-Centered Radical-Mediated Cascade Amidoglycosylation of Glycals” Organic Letters, 2021, 23, 1222 – 1227.
16) Zhiqiang Pan, Fengchi Hu, Di Jiang, Yuchang Liu, Chengfeng Xia* “Chichibabin pyridinium synthesis via oxidative decarboxylation of photoexcited α-enamine acids” Chemical Communications, 2021, 57, 1222 – 1225.
17) Haiyang Wang, Xiaogang Tong, Yanman Huo, Jiaying Tang, Chengfeng Xia* “Potassium methoxide/disilane-mediated formylation of aryl iodides with DMF at room temperature” Organic Chemistry Frontiers, 2020, 7, 4074 – 4079.
18) Kangjiang Liang, Qian Liu, Lei Shen, Xipan Li, Delian Wei, Liyan Zheng, Chengfeng Xia* “Intermolecular oxyarylation of olefins with aryl halides and TEMPOH catalyzed by the phenolate anion under visible light” Chemical Science 2020, 11, 6996 – 7002.
19) Zhiqiang Pan, Yuchang Liu, Fengchi Hu, Qinglong Liu, Wenbin Shang, Chengfeng Xia* “Photochemical α-carboxyalkylation of tryptophols and tryptamines via C–H functionalization” Chemical Communications 2020, 56, 4930 – 4933.
20) Tao Li, Kangjiang Liang, Yang Zhang, Dongyan Hu, Zhixian Ma, Chengfeng Xia* “Three-Component Minisci Reaction with 1,3-Dicarbonyl Compounds Induced by Visible Light” Organic Letters 2020, 22, 2386 – 2390.
21) Kangjiang Liang, Tao Li, Na Li, Yang Zhang, Lei Shen, Zhixian Ma, Chengfeng Xia* “Redox-neutral photochemical Heck-type arylation of vinylphenols activated by visible light” Chemical Science 2020, 11, 2130 - 2135.
22) Zhiqiang Pan, Yuchang Liu, Fengchi Hu, Qinglong Liu, Wenbin Shang, Xu Ji, Chengfeng Xia* “Enantioselective Synthesis of Spiroindolines via Cascade Isomerization/Spirocyclization/Dearomatization Reaction” Organic Letters 2020, 22, 1589 – 1593.
23) Xiaogang Tong, Bingfei Shi, Qian Liu, Yanman Huo, Chengfeng Xia* “Retro-biosynthetic construction of corynanthe alkaloid skeletons from rhynchophylline alkaloids” Organic & Biomolecular Chemistry 2019, 17, 8062 – 8066.
24) Xiaogang Tong, Bingfei Shi, Kangjiang Liang, Qian Liu, Chengfeng Xia* “Enantioselective Total Synthesis of (+)-Flavisiamine F via Late-Stage Visible-Light-Induced Photochemical Cyclization” Angewandte Chemie International Edition 2019, 58, 5443 - 5446.
25) Kangjiang Liang, Na Li, Yang Zhang, Tao Li, Chengfeng Xia* “Transition-metal-free a-arylation of oxindoles via visible-light-promoted electron transfer” Chemical Science 2019, 10, 3049 - 3053.
