熊文勇

邮箱：xwy@ynu.edu.cn

职称：研究员(博士生导师)

地址：药学院1403

教育经历：

1999.09-2004.07，中国科学院昆明动物研究所，动物学，理学博士

1995.09-1999.07，陕西师范大学生命科学学院，生物学，理学学士

工作经历：

2023.05-至今， 云南大学，药学院，研究员

2021.05-2023.04，云南大学，教育部自然资源药物化学重点实验室，研究员

2011.03-2021.04，中国科学院昆明植物研究所，西部植物资源与持续利用国家重点实验室，研究员

2007.07-2011.02，美国康奈尔大学Weill医学院，生物化学系， 博士后

2004.09-2007.06，美国南加州大学Keck医学院，生理与神经科学系/Zilkha神经遗传研究所，博士后

研究领域：

1. 植物天然产物治疗代谢性疾病的药效与药理研究

2. 活性化合物的药代、药动与安全性评价

奖励荣誉：

1. 中国科学院“百人计划”人才计划，2012年

2. 云南省“高端科技人才引进”人才计划，2013年

职教课程与教学成果：

1. 主讲研究生《化学生物学进展》

2. 主讲本科生《药物毒理学与病理学》

科研项目：

1. 国家自然科学基金委，基于GPR30研究人参皂苷Rg5激活Gq信号调控脂肪细胞棕色化的新机制，2027.01-2030.12（主持）

2. 云南省重大科技专项计划，治疗代谢综合征创新三七组分的临床前预研究，2024.01-2026.12（主持）

3. 云南省基础研究计划重点项目，三七中稀有人参皂苷治疗代谢综合征的作用机制研究，2024.03-2027.02（主持）

4. 国家重点研发计划，滇缅地区特有传统药用植物的活性物质基础及其转化研究，2020.12-2023.11（参加）

5. 国家重点研发计划，栀子等三种高品质江西道地中药材规模化种植及精准扶贫示范研究，2018.01-2021.12（参加）

6. 云南省基础研究计划重点项目，一种天然倍半萜化合物的抗2型糖尿病机理研究，2017.06-2020.05（主持）

7. 国家自然科学基金面上项目，LLGL1 调控小GTP酶在胰岛素诱导GLUT4 膜转运中的机制研究，2013.01-2016.12（主持）

8. 云南省高端科技人才引进计划项目，治疗2型糖尿病先导化合物的发现及作用机制研究，2014.01-2018.12，主持

9. 中国科学院百人计划项目，治疗二型糖尿病的天然化合物筛选与分子作用机理研究，2013.01-2016.12（主持）

近五年代表性论文：（中科院/新锐期刊分区Ⅰ区文章13篇；II区文章7篇）

1. Wenli Chen#, Yanting Lu#, Xiangxiang Liu, Bangrui Huang, Daowei Liu, Bilian He, Zhiming Zhao, Qian Wang, Jixi Li, Wenyong Xiong*. AS160 Overexpression Protects Against β-cell Failure in Hyperglycemic Mice by Interacting with HSPA8 to Regulate Mitophagy. Acta Physiologica. 2026, accepted. (2025年中科院期刊分区-大类I区)

2. Yongsheng Fang#, Han Liu#, Fakun Jiang, Qian Lu, Bangrui Huang, Chuanjun Mao, Qian Long, Xiaodong Yang*, Jun Cao* and Wenyong Xiong*. Euphorbia factor L3 ameliorates hepatic steatosis by activating LKB1-AMPK signaling pathway-regulated lipid metabolism. Bioorganic Chemistry, 2026,179:110008. doi.org/10.1016/j.bioorg.2026.110008. (2025年中科院期刊分区-小类Ⅰ区)

3. Chenxi Quan, Zhouwei Wu, Guilin Hu, Xiaocui Liu, Yuancao Shu, Xingrong Peng, Lin Zhou, Wenyong Xiong, Minghua Qiu*. From microbial succession to precision fermentation: Enhancing Yunnan coffee flavor with a defined native yeast starter guided by multi-omics. Food Research International. 2026,236:119157. doi.org/10.1016/j.foodres.2026.119157. (2025年中科院期刊分区-大类Ⅰ区)

4. Bangrui Huang#, Daowei Liu#, Fakun Jiang, Zihui Wang, Chuanjun Mao, Qian Lu, Tao Chen, Chun Xie, Wenli Chen*, Qian Wang*, Wenyong Xiong*.  D2R Agonist Ropinirole Cooperates with Metformin to Modulate Thermogenesis and Ameliorate Obesity-related Metabolic Disorders in Mice. Diabetes and Metabolism Journal. 2026, in press. (2025年中科院期刊分区-大类II区)

5. Wenli Chen#, Weiyi Cui#, Yan Xu, Xuelian Wang, Xueting Sun, Jing Ren, Ning Hou, Wenyong Xiong*, Rui-Ping Xiao*, Xiuqin Zhang*. Loss of Slc39a5 in α-cells impairs glucose metabolism by chronically increasing glucagon. Journal of Advanced Research. 2025 Nov 10: S2090-1232(25)00908-7. DOI: 10.1016/j.jare.2025.11.013. (2025年中科院期刊分区-大类Ⅰ区)

6. Xiangxiang Liu#, Yuanzhao Hu#, Liangwei Wu, Yiwen Zhang, Lei Sang, Yake Gao, Lei He, Wenyong Xiong*, Shengyu Yang*, Jianwei Sun*. FSCN1-mediated hepatic gluconeogenesis is indispensable for neonatal mice survival. Acta Biochimica et Biophysica Sinica. 2025,57(x): 1–11. DOI: 10.3724/abbs.2025146. (2025年中科院期刊分区-大类II区)

7. Yongsheng Fang#, Zhiyun Zhu#, Chun Xie, Dazhen Xia, Huimin Zhao, Zihui Wang, Qian Lu, Caimei Zhang, Wenyong Xiong*, Xiaodong Yang*. Design and synthesis of novel saponin-triazole derivatives in the regulation of adipogenesis. Chinese Journal of Natural Medicines. 2025,23(8): 920-931. DOI:10.1016/S1875-5364(25)60830-2. (2026年新锐期刊分区-大类Ⅰ区)

8. Yixian Li, Shibo Chen, Yuantang Duan, Zilong Guo, Wenyong Xiong*, Hongmei Zhao*, Xiaohong Cheng*. Polycatenar mesogens based on phenothiazine imine: Liquid crystal and photophysical properties. Dyes and Pigments. 2025,240:112817. DOI:10.1016/j.dyepig.2025.112817. (2025年中科院期刊分区-小类Ⅰ区)

9. Qiong Xiao#, Yuantang Duan#, Yifei Chen, Daowei Liu, Wenyong Xiong*, Xiaohong Cheng*. Synthesis, self-assembly, photo-reactivity and application of an α-cyanostilbene pyridinium luminescent ionic liquid crystal. Journal of Molecular Structure. 2025,1338. DOI: 10.1016/j.molstruc.2025.142327. (2025年中科院期刊分区-大类II区)

10. Zilong Guo#, Fen Wang#, Yuantang Duan, Yifei Chen, Daowei Liu, Wenyong Xiong*, Xiaohong Cheng*. Rod-like D-π-A-π-D Schiff base liquid crystal for continuous ion sensing, live cell imaging, fingerprint imaging and WLED. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2025,337:126090. DOI: 10.1016/j.saa.2025.126090. (2026年新锐期刊分区-小类Ⅰ区)

11. Qian Wang#, Gui-Lin Hu#, Ming-Hua Qiu, Jun Cao*, Wen-Yong Xiong*. Coffee, tea, and cocoa in obesity prevention: mechanisms of action and future prospects. Current Research in Food Science. 2024,8:100741. DOI: 10.1016/j.crfs.2024.100741. (2025年中科院期刊分区-大类Ⅰ区)

12. Yuanzhi Chen, Zhicheng He, Shuting Yang, Cheng Chen, Wenyong Xiong, Yingying He* & Shubai Liu*. RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells. Journal of Translational Medicine. 2023,21:886. DOI:10.1186/s12967-023-04762-8. (2026年新锐期刊分区-大类Ⅰ区)

13. Meiling Shen#, Lingfeng Li#, Yue Li, Xi Gu, Longhui Bai, Chengfeng Xia, Wenyong Xiong*, Zhili Zuo*. Discovery of potential novel TRPC5 inhibitors by virtual screening and bioassay. Bioorganic & Medicinal Chemistry. 2023,94: 117477. DOI:10.1016/j.bmc.2023.117477. (2025年中科院期刊分区-小类II区)

14. Ling Yang, Linzi Li, Qian Lu, Lingfeng Li, Chun Xie, Fakun Jiang, Hongbing Li, Ai Zhao*, Qian Wang*, Wenyong Xiong*. Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue. European Journal of Pharmacology. 2023,956:175942. DOI: 10.1016/j.ejphar.2023.175942. (2025年中科院期刊分区-小类II区)

15. Qian Wang#, Guilin Hu#, Qian Lu, Defu Hong, Abdulbaset Al-Romaima, Minghua Qiu*, Wenyong Xiong*. Identification and screening of novel diterpenoids of roasted arabica coffee in regulating lipid content of white adipocytes. Food & Function. 2023,14(11):5138-5150. DOI: 10.1039/d3fo01130e. (2026年新锐期刊分区-大类Ⅰ区)

16. Dao-Wei Liu#, Yan-Song Ye#, Chao-Guang Huang, Qian Lu, Ling Yang, Qian Wang, Huan Wang, Xia Liu, Chuan-Bo Jing, Gang Xu*, Wen-Yong Xiong*. Sampsonione F suppresses adipogenesis via activating p53 pathway during the mitotic clonal expansion progression of adipocyte differentiation. European Journal of Pharmacology. 2022,925:175002. DOI: 10.1016/j.ejphar.2022.175002. (2025年中科院期刊分区-小类II区)

17. Xing-Rong Peng#, Qian Wang#, Hai-Guo Su, Lin Zhou, Wen-Yong Xiong* and Ming-Hua Qiu*. Anti-Adipogenic Lanostane-Type Triterpenoids from the Edible and Medicinal Mushroom Ganoderma applanatum. Journal of Fungi. 2022,8(4):331. DOI: 10.3390/jof8040331. (2025年中科院期刊分区-大类II区)

18. Xing-Rong Peng#, Qian Wang#, Hui-Rong Wang, Kun Hua, Wen-Yong Xiong*, Ming-Hua Qiu*. FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma. Bioorganic Chemistry. 2021,116:105338. DOI: 10.1016/j.bioorg.2021.105338. (2025年中科院期刊分区-小类Ⅰ区)

19. Hai-Guo Su#, Qing Wang#, Lin Zhou, Xing-Rong Peng*, Wen-Yong Xiong*, Ming-Hua Qiu*. Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents. Bioorganic Chemistry. 2021,112:104977. DOI: 10.1016/j.bioorg.2021.104977. (2025年中科院期刊分区-小类Ⅰ区)

20. Li-bin Wang#, Dan-ni Wang#, Li-gang Wu, Jia Cao, Jin-hai Tian, Rong Liu, Rong Ma, Jing-jing Yu, Jia Wang, Qi Huang, Wen-Yong Xiong*, Xu Zhang*. Homoharringtonine inhibited breast cancer cells growth via miR-18a-3p/AKT/mTOR signaling pathway. International Journal of Biological Sciences. 2021,17(4):995-1009. DOI: 10.7150/ijbs.44907. (2025年中科院期刊分区-大类Ⅰ区)