熊文勇

邮箱：xwy@ynu.edu.cn

职称：研究员（博士生导师）

地址：云南大学呈贡校区药学院，国家重点实验室1栋1403

教育经历

1. 1999.09-2004.08，中国科学院昆明动物研究所，动物学， 理学博士

2. 1995.09-1999.07，陕西师范大学生命科学学院，生物学，理学学士

工作经历

1. 2023.05-至今， 云南大学，药学院，研究员

2. 2021.05-2023.04，云南大学，教育部自然资源药物化学重点实验室，研究员

3. 2011.03-2021.04，中国科学院昆明植物研究所，西部植物资源与持续利用国家重点实验室，研究员

4. 2007.07-2011.02，美国康奈尔大学Weill医学院，生物化学系， 博士后

5. 2004.09-2007.06，美国南加州大学Keck医学院，生理与神经科学系/Zilkha神经遗传研究所，博士后

研究领域

药用植物及天然产物在治疗代谢性疾病（肥胖、2型糖尿病、高血脂、MAFLD等）中的药效及药理机制研究；调控2型糖尿病等代谢性疾病的分子机制研究。

奖励荣誉和学术任职

1.中国科学院“百人计划”获得者

2.云南省“高端科技人才引进计划”获得者

3. 《中国药理学通报》青年编委会委员

执教课程与教学成果

主讲研究生《化学生物学进展》、本科生《药物毒理学与病理学》

科研项目

1. 云南省科技厅-重大科技专项计划项目，2024.1-2026.12，治疗代谢综合征创新三七组分的临床前预研究 (主持)

2. 国家重点研发计划项目，2020.12-2023.11，滇缅地区特有传统药用植物的活性物质基础及其转化研究 (参与)

3. 国家重点研发计划项目，2018.1-2021.12，栀子等三种高品质江西道地中药材规模化种植及精准扶贫示范研究 (参与)

4. 云南省基础研究计划-重点项目，2017.06-2020.05，一种天然倍半萜化合物的抗2型糖尿病机理研究 (主持)

5. 云南省基础研究计划-高端科技人才引进计划项目，2014.01-2018.12，治疗2型糖尿病先导化合物的发现及作用机制研究 (主持)

6. 国家自然科学基金-面上项目，2013.01-2016.12，LLGL1 调控小GTP酶在胰岛素诱导GLUT4 膜转运中的机制研究 (主持)

7. 中国科学院-百人计划项目，2013.01-2016.12，治疗二型糖尿病的天然化合物筛选与分子作用机理研究 (主持)

代表性论文

1. Qian Wang#; Gui-Lin Hu#; Ming-Hua Qiu; Jun Cao*; Wen-Yong Xiong*. Coffee, tea, and cocoa in obesity prevention: mechanisms of action and future prospects. Curr. Res. Food Sci. 2024, 8:100741.

2. Ling Yang, Linzi Li, Qian Lu, Lingfeng Li, Chun Xie, Fakun Jiang, Hongbing Li, Ai Zhao*, Qian Wang*, Wenyong Xiong*. Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue. Eur. J. Pharmacol. 2023, 956:175942.

3. Qian Wang#, Guilin Hu#, Qian Lu, Defu Hong, Abdulbaset Al-Romaima, Minghua Qiu*, Wenyong Xiong*. Identification and screening of novel diterpenoids of roasted arabica coffee in regulating lipid content of white adipocytes. Food Funct. 2023. 14(11):5138-5150.

4. Dao-Wei Liu#, Yan-Song Ye#, Chao-Guang Huang, Qian Lu, Ling Yang, Qian Wang, Huan Wang, Xia Liu, Chuan-Bo Jing, Gang Xu*, Wen-Yong Xiong*. Sampsonione F suppresses adipogenesis via activating p53 pathway during the mitotic clonal expansion progression of adipocyte differentiation. Eur. J. Pharmacol. 2022, 925, 175002.

5. Xing-Rong Peng#, Qian Wang#, Hui-RongWang, Kun Hua, Wen-Yong Xiong*, Ming-Hua Qiu*. FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma. Bioorg. Chem. 2021, 116, 105338.

6. Hai-Guo Su#, Qing Wang#, Lin Zhou, Xing-Rong Peng*, Wen-Yong Xiong*, Ming-Hua Qiu*. Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents. Bioorg. Chem. 2021, 112, 104977.

7. Li-bin Wang#, Dan-Ni Wang#, Li-gang Wu, Jia Cao, Jin-hai Tian, Rong Liu, Rong Ma, Jing-jing Yu, Jia Wang, Qi Huang, Wen-yong Xiong*, Xu Zhang*. Homoharringtonine inhibited breast cancer cells growth via miR-18a-3p/AKT/mTOR signaling pathway. Int. J. Biol. Sci. 2021, 17(4), 995-1009.

8. Hai-Guo Su#, Qian Wang#, Lin Zhou, Xing-Rong Peng*, Wen-Yong Xiong*, Ming-Hua Qiu*. Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes. Bioorg. Chem. 2020, 104, 104263.

9. Qian Wang, Rong-Fang Mu, Xing Liu, Hui-Min Zhou, Yu-Hui Xu, Wan-Ying Qin, Chong-Ren Yang, Li-Bin Wang*, Hai-Zhou Li*, Wen-Yong Xiong*. Steaming Changes the Composition of Saponins of Panax notoginseng (Burk.) F.H. Chen That Function in Treatment of Hyperlipidemia and Obesity. J. Agric. Food. Chem. 2020, 68(17), 4865-4875.

10. Fang Wang#, Xiaoyan Yang#, Yanting Lu, Zhenghui Li, Yuhui Xu, Jing Hu, Jikai Liu* and Wenyong Xiong*. The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake. J. Biol. Chem. 2019, 294(27), 10415-10427.

11. Yangang Pan#, Yuebin Zhang#, Pianchou Gongpan#, Bin Wang, Bingqian Xu, Yuping Shan*, Wenyong Xiong*, Guohui Li* and Hongda Wang*. Single molecule glucose transporting process revealed by force tracing and molecular dynamics simulations. Nanoscale Horiz. 2018, 3(5), 517-524.

12. Qiuyan Yan, Yanting Lu, Lulu Zhou, Junling Chen, Haijiao Xu, Mingjun Cai, Yan Shi, Junguang Jiang, Wenyong Xiong*, Jing Gao,* Hongda Wang*. Mechanistic insights into GLUT1 activating and clustering revealed by super-resolution imaging. Proc. Natl. Acad. Sci. U.S.A. 2018, 115 (27), 7033-7038.

13. Yuhui Xu, Yanfen Niu, Yuan Gao, Fang Wang, Wanying Qin, Yanting Lu, Jing Hu, Li Peng, Jikai Liu*, and Wenyong Xiong*. Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice. J. Nat. Prod. 2017, 80(8), 2319−2327.

14. Junling Chen, Tianzhou, Liu, Jing Gao, Lan Gao, Lulu Zhou, Mingjun Cai, Yan Shi, Wenyong Xiong, Junguang Jiang, Ti Tong*, Hongda Wang*. Variation in carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging. Adv. Sci. 2016, 3(12), 1600270.

15. Qinghua Kong#, Lan Gao#, Yanfen Niu, Pianchou Gongpan, Yuhui Xu, Yan Li*, Wenyong Xiong*. RACK1 is required for adipogenesis. Am. J. Physiol.-Cell. Ph. 2016, 311(5), C831-C836.