高 峰（教授，博士生导师）

研究生招生专业：化学、药学、生物与医药

地址：云南大学呈贡校区自然资源药物化学教育部重点实验室1201

电子信箱：gaofeng@ynu.edu.cn

教育工作经历：

南开大学化学系学士、硕士。中山大学化学与化学工程学院博士。中山大学化学与化学工程学院讲师。教育部国家公派留学博士后（美国佐治亚理工学院）。人社部香江学者博士后（香港科技大学）。云南大学化学科学与工程学院/自然资源药物化学教育部重点实验室/药学院副教授、教授。

研究领域：

荧光/磷光过渡金属配合物及其纳米制剂与递送系统的设计及抗肿瘤光动力、声动力、光热、化疗等多机制协同治疗和成像。基于量子化学理论计算的化合物结构、光物理性质、光化学性质及生物活性的关系。

科研项目：

1、国家自然科学基金，单分子光声热多重成像引导和激活的多模式协同抗肿瘤诊疗一体化平台，2025年01月至2028年12月，主持。

2、国家自然科学基金，多核异核钌锇配合物抗肿瘤活性及机理研究，2022年01月至2025年12月，主持。

3、云南省重点项目，2024年03月至2027年02月，主持。

4、首批云南省万人计划青年拔尖人才（现“兴滇英才支持计划”），2018年。

代表性论文（近年）：

1、Ran Song, Run-Yu Zhao, Ru Yan, Xue-Lian Li, Li-Zhen Zeng, Zhongyan Cai, Jingbo Chen*, Xiaoxia Ren*, Xiaohong Cheng*, Feng Gao*, Nonemissive Ruthenium Complexes for Near Infrared-II Photodynamic, Photothermal, Sonodynamic, and Sonothermal Therapy Against Drug-Resistant Cancer, Journal of Medicinal Chemistry, 2025, 68, 17653-17666.

2、Yun Li, Xiao-Qi Zheng, Ding Wang, Chun-Lai Wei, Ya-Man Huang, Meng-Chi Han, Ze-Ming Wang, Xue-Lian Li, Qing-Fang Li, Zhongyan Cai, Xiaoxia Ren*, Feng Gao*, Cyclometalated Iridium(III) Complexes with Optimally Allocated Excited-State Energy for Near-Infrared Photodynamic and Photothermal Therapy, Inorganic Chemistry, 2025, 64, 19044-19054.

3、Xiao-Xia Ren, Xue-Lian Li, Run-Yu Zhao, Yun Li, Ran Song, Meng-Chi Han, Yu-Fei Yan, Li-Zhen Zeng, Zhong-Yan Cai, Feng Gao*, Dinuclear Ru(II) Complexes for Synergetic Photodynamic, Photothermal, and Sonodynamic Therapy against Cisplatin-Resistant Cancer, Inorganic Chemistry, 2025, 64, 9596-9607.

4、Li-Zhen Zeng, Xue-Lian Li, Yu-Ang Deng, Run-Yu Zhao, Ran Song, Yu-Fei Yan, Meng-Fan Wang, Xiang-Han Wang, Xiaoxia Ren*, Feng Gao*, Dinuclear Dicationic Iridium Complexes for Highly Synergistic Photodynamic and Photothermal Therapy to Chemo-Resistant Cancer, Inorganic Chemistry, 2025, 64, 967-977.

5、Yu-Fei Yan, Xue-Lian Li, Li-Zhen Zeng, Qishuai Liu, Zhongyan Cai, Yanrong Ren, Xiaoxia Ren*, Feng Gao*, Antitumor Cream: Transdermal Hydrogel Containing Liposome-Encapsulated Ruthenium Complex for Infrared-Controlled Multimodal Synergistic Therapy, Advanced Healthcare Materials, 2025, 14, 2403563.

6、Xue-Lian Li, Meng-Fan Wang, Li-Zhen Zeng, Guo-Kui Li, Run-Yu Zhao, Fu-Dan Liu, Yun Li, Yu-Fei Yan, Qishuai Liu, Zhao Li, Hongbin Zhang, Xiaoxia Ren*, Feng Gao*, Bithiophene-Functionalized Infrared Two-Photon Absorption Metal Complexes as Single-Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy, Angewandte Chemie International Edition, 2024, 63, e202402028.

7、Xue-Lian Li, Li-Zhen Zeng, Rong Yang, Xu-Dan Bi, Yang Zhang, Ruo-Bing Cui, Xin-Xi Wu, Feng Gao*, Iridium(III)-Based Infrared Two-Photon Photosensitizers: Systematic Regulation of Their Photodynamic Therapy Efficacy, Inorganic Chemistry, 2023, 62, 16122-16130.

8、Shi-Jie Tang, Qing-Fang Li, Meng-Fan Wang, Rong Yang, Li-Zhen Zeng, Xue-Lian Li, Rui-Dong Wang, Hongbin Zhang, Xiaoxia Ren, Dan Zhang, Feng Gao*, Bleeding the Excited State Energy to the Utmost: Single-Molecule Iridium Complexes for In Vivo Dual Photodynamic and Photothermal Therapy by an Infrared Low-Power Laser, Advanced Healthcare Materials, 2023, 12, 2301227.

9、Yu-Ang Deng, Shi-Jie Tang, Meng-Fan Wang, Xiaoxia Ren, Xue-Lian Li, Li-Zhen Zeng, Dan-Ni Ren, Meng-Ru Wang, Wei-Lie Xiao, Zhong-Yan Cai, Dan Zhang, Hongbin Zhang, Feng Gao*, Heterometallic ruthenium-osmium complexes: dual photodynamic and photothermal therapy for melanoma and drug-resistant lung tumor in vivo, Inorganic Chemistry Frontiers, 2023, 10, 4552-4561.

10、Shi-Jie Tang, Meng-Fan Wang, Rong Yang, Meng Liu, Qing-Fang Li, Feng Gao*, More-Is-Better Strategy for Constructing Homoligand Polypyridyl Ruthenium Complexes as Photosensitizers for Infrared Two-Photon Photodynamic Therapy, Inorganic Chemistry, 2023, 62, 8210-8218.

11、Meng-Fan Wang, Rong Yang, Shi-Jie Tang, Yu-Ang Deng, Guo-Kui Li, Dan Zhang, Daomei Chen, Xiaoxia Ren, Feng Gao*, In vivo Realization of Dual Photodynamic and Photothermal Therapy for Melanoma by Mitochondria Targeting Dinuclear Ruthenium Complexes under Civil Infrared Low-power Laser, Angewandte Chemie International Edition, 2022, 61, e202208721.

12、Meng-Fan Wang, Yu-Ang Deng, Qing-Fang Li, Shi-Jie Tang, Rong Yang, Xiaoxia Ren, Dan Zhang, Feng Gao*, Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents in vivo, Chemical Communications, 2022, 58, 12676-12679.

课程教学：

先后主讲《无机化学》、《无机化学实验》、《普通化学》、《基础化学实验》、《物理化学》、《配位化学》、《生物无机化学》、《精细化学品分析与应用》、《药学基础化学》、《现代分析技术》等10余门本科生、研究生基础课程。