王磊
邮箱：wanglei2024@ynu.edu.cn
职称：助理研究员（硕士生导师）
地址：云南大学呈贡校区药学院，国重楼1栋1223
教育经历
2020.09-2024.6，中国药科大学，药物化学，博士
2017.09-2020.06，福建中医药大学-海军军医大学联合培养，药物化学，医学硕士
2012.9-2016.6，蚌埠医科大学，药学，医学学士
工作经历
2024 - 至今，云南大学，药学院/教育部自然资源药物化学重点实验室，助理研究员
研究领域
1. 靶向肿瘤和神经退行性疾病的小分子药物研发与作用机制研究
2. 肿瘤精准治疗方法的开发
奖励荣誉和学术任职
无
执教课程与教学成果
主讲本科生课程：《药物化学》、《天然药物化学实验》、《天然药物分子的修饰与改造》、《天然药物研发案例分析》
科研项目
1) 国家自然科学基金青年科学基金项目（C类），82504599，近红外响应异喹啉生物碱的“光-化”疗协同抗肿瘤研究，2026-01-01至2028-12-31，在研，主持；
2) 云南省基础研究计划面上项目，天然产物小檗碱的结构修饰与改造，2026-06-01至2029-05-31，在研，主持；
3) 江苏省研究生科研创新计划项目，KYCX21_0668，BChE-HDAC双靶点抑制剂的抗AD活性研究，2021年3月-2022年3月，主持，已结题。
代表性论文
1) Lei Wang,# Ying Wu,# Xiangqian Tan, and Chengfeng Xia*, Visible and Near-Infrared Photopharmacology: Wavelength-Redshift Strategies for Spatiotemporally Precise Therapeutics. J. Med. Chem. 2026, 69, 1878-1915 (IF 6.800，中科院1区Top)
2) Shanchao Wu,# Lei Wang,# Yingqi Song,# Changlu Li# Xiaoyao Lu, Qingwei Bu, Keliang Li, Yuping Chen, Hua Sun, Guang Liang,* Gaozhi Chen,* and Chunquan Sheng*，Discovery of Benzodiazepinepyrimidine Scaffold Derivatives as Potent Doublecortin-Like Kinase 1 (DCLK1) Inhibitors for the Treatment of Acute Inflammatory Diseases. J. Med. Chem. 2025, 68, 21560-21576 (IF 7.300，中科院1区Top)
3) Lei Wang, Tianyu Sun, Tengfei Zhen, Wei Li, Suyu Wang, Feng Feng*, Yao Chen*, Haopeng Sun*. Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer’s Disease. J. Med. Chem. 2024, 67, 6793−6809 (IF 7.300，中科院1区Top)
4) Lei Wang, Kun Fang, Junfei Cheng, Yu Li, Yahui Huang, Shuqiang Chen, Guoqiang Dong*, Shanchao Wu*, Chunquan Sheng*, Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer. J. Med. Chem. 2020;63(2):696−713. (IF 6.054，中科院1区Top)
5) Chenxi Du#, Lei Wang#, Qianwen Guan, Hongyu Yang, Tingkai Chen, Yijun Liu, Qihang Li, Weiping Lyu, Xin Lu, Ying Chen, Yang Liu, Hui Liu, Feng Feng, Wenyuan Liu, Zongliang Liu, Wei Li*, Yao Chen*, and Haopeng Sun*. N‑Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer’s Disease. J. Med. Chem. 2022, 65, 11365−11387 (IF 8.039，中科院1区Top)
6) Lei Wang, Chenxi Du, Hui Liu, Weimin Qiu, Xin Lu, Yanyu Hu, Yueqing Li, Tianyu Sun, Yao Chen, Haopeng Sun*. A Practical and High-Affinity Fluorescent Probe for Butyrylcholinesterase: A Good Strategy for Binding Affinity Characterization. Chin. J. Chem. 2022, 40, 1285−1292. (Cover art, IF 5.560，中科院1区)
7) Lei Wang, Ziming Gao, Tianyu Sun, Chen Chen, Jiawei Zhu, Suyu Wang, Yao Chen*, Haopeng Sun*. Optical Control of Butyrylcholinesterase (BChE) Activity via Photoswitchable Azobenzene for Potential Treatment of Alzheimer's Disease. Bioorg. Chem. 2024, 153, 107845. (IF 4.50，中科院2区)
8) Lei Wang, Tianyu Sun, Zhenqi Wang, Hui Liu, Weimin Qiu, Xu Tang, Huanchao Guo, Peng Yang*, Yao Chen*, and Haopeng Sun*. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer’s Disease. ACS Chem. Neurosci. 2023, 14, 3226−3248 (IF 5.000，中科院3区)
9) Lei Wang, Zixuan Yang, Tianyu Ni, Wencai Shi, Yunbo Guo, Keliang Li, Anzhe Shi, Shanchao Wu*, Chunquan Sheng*, Discovery of Pyrazolone Spirocyclohexadienone Derivatives with Potent Antitumor Activity. Bioorg. Med. Chem. Lett. 2020;30(1):126662. (IF 2.448，中科院4区)
