王磊
邮箱：wanglei2024@ynu.edu.cn
职称：讲师
地址：云南大学呈贡校区药学院，国重楼1栋1421
教育经历
2020.09-2024.6，中国药科大学，药物化学，博士
2017.09-2020.06，福建中医药大学-海军军医大学联合培养，药物化学，医学硕士
2012.9-2016.6，蚌埠医科大学，药学，医学学士
工作经历
2024 - 至今，云南大学，药学院，教育部自然资源药物化学重点实验室，讲师
2017.7 – 2018.8，海军军医大学药学院，科研助理
研究领域
1. 天然产物的成药性研究；
2. 药物合成及活性研究。
奖励荣誉和学术任职
无
执教课程与教学成果
无
科研项目
1) 江苏省研究生科研创新计划项目，KYCX21_0668，BChE-HDAC双靶点抑制剂的抗AD活性研究，2021年3月-2022年3月，主持，已结题
代表性论文
1) Lei Wang, Tianyu Sun, Tengfei Zhen, Wei Li, Suyu Wang, Feng Feng*, Yao Chen*, Haopeng Sun*. Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer’s Disease. J. Med. Chem. 2024, 67, 6793−6809 (IF 7.300，中科院1区Top)
2) Lei Wang, Kun Fang, Junfei Cheng, Yu Li, Yahui Huang, Shuqiang Chen, Guoqiang Dong*, Shanchao Wu*, Chunquan Sheng*, Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer. J. Med. Chem. 2020;63(2):696−713. (IF 6.054，中科院1区Top)
3) Chenxi Du#, Lei Wang#, Qianwen Guan, Hongyu Yang, Tingkai Chen, Yijun Liu, Qihang Li, Weiping Lyu, Xin Lu, Ying Chen, Yang Liu, Hui Liu, Feng Feng, Wenyuan Liu, Zongliang Liu, Wei Li*, Yao Chen*, and Haopeng Sun*. N‑Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer’s Disease. J. Med. Chem. 2022, 65, 11365−11387 (co-first author, IF 8.039，中科院1区Top)
4) Lei Wang, Chenxi Du, Hui Liu, Weimin Qiu, Xin Lu, Yanyu Hu, Yueqing Li, Tianyu Sun, Yao Chen, Haopeng Sun*. A Practical and High-Affinity Fluorescent Probe for Butyrylcholinesterase: A Good Strategy for Binding Affinity Characterization. Chin. J. Chem. 2022, 40, 1285−1292. (Cover art, IF 5.560，中科院1区)
5) Lei Wang, Ziming Gao, Tianyu Sun, Chen Chen, Jiawei Zhu, Suyu Wang, Yao Chen*, Haopeng Sun*. Optical Control of Butyrylcholinesterase (BChE) Activity via Photoswitchable Azobenzene for Potential Treatment of Alzheimer's Disease. Bioorg. Chem. 2024, 153, 107845. (IF 4.50，中科院2区)
6) Lei Wang, Tianyu Sun, Zhenqi Wang, Hui Liu, Weimin Qiu, Xu Tang, Huanchao Guo, Peng Yang*, Yao Chen*, and Haopeng Sun*. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer’s Disease. ACS Chem. Neurosci. 2023, 14, 3226−3248 (IF 5.000，中科院3区)
7) Lei Wang, Zixuan Yang, Tianyu Ni, Wencai Shi, Yunbo Guo, Keliang Li, Anzhe Shi, Shanchao Wu*, Chunquan Sheng*, Discovery of Pyrazolone Spirocyclohexadienone Derivatives with Potent Antitumor Activity. Bioorg. Med. Chem. Lett. 2020;30(1):126662. (IF 2.448，中科院4区)
8) Ying Wu, Lei Wang, Yahui Huang, Guoqiang Dong*, Chunquan Sheng*. Nicotinamide Phosphoribosyltransferase (NAMPT) is a New Target of Antitumor Agent Chidamide. ACS Med. Chem. Lett. 2020;11(1):40−44. (IF 3.737，中科院3区)
9) Qianwen Guan, Shuaishuai Xing, Lei Wang, Jiawei Zhu, Can Guo, Chunlei Xu, Qun Zhao, Yulan Wu, Yao Chen*, and Haopeng Sun*, Triazoles in Medicinal Chemistry: Physicochemical Properties, Bioisosterism, and Application. J. Med. Chem. 2024, 67, 10, 7788–7824（IF 7.300，中科院1区Top）
10) Weimin Qiu, Hui Liu, Yijun Liu, Xin Lu, Lei Wang, Yanyu Hu, Feng Feng, Qi Li, Haopeng Sun, Regulation of beta-amyloid for the treatment of Alzheimer's disease: Research progress of therapeutic strategies and bioactive compounds. Med Res Rev. 2023; 43: 1091-1140.（IF 13.3，中科院1区Top）
11) Hui Liu, Weimin Qiu, Tianyu Sun, Lei Wang, Chenxi Du, Yanyu Hu, Wenyuan Liu, Feng Feng, Yao Chen*, Haopeng Sun*, Therapeutic strategies of glioblastoma (GBM): The current advances in the molecular targets and bioactive small molecule compounds.Acta Pharm. Sin. B, 2022, 12, 4, 1781-1804（IF 14.5，中科院1区Top）
12) Tianyu Sun, Tengfei Zhen, Chrisanta Hamis Harakandi, Lei Wang, Huanchao Guo, Yao Chen, Haopeng Sun. New insights into butyrylcholinesterase: Pharmaceutical applications, selective inhibitors and multitarget-directed ligands. Eur. J. Med. Chem. 2024;275:116569. (IF = 6.0, 中科院2区)
