居晓曼

邮箱：juxiaoman@ynu.edu.cn

职称：助理研究员

地址：云南大学呈贡校区药学院，国家重点实验室1栋1105

教育经历：

2011.09-2015.07，济宁医学院，药物制剂，理学学士

2015.09-2018.07，苏州大学，药学，理学硕士

2018.09-2021.07，中国科学院昆明植物研究所，药理学，理学博士

工作经历：

2021.10-2025.09，徐州医科大学，基础医学院，博士后

2026.04-至今，云南大学，药学院，助理研究员

研究领域：

1. 肿瘤免疫微环境与免疫逃逸机制研究；

2. 肿瘤免疫调控新靶点及免疫增敏候选药物发现。

奖励荣誉：

无

职教课程与教学成果：

无

科研项目：

1.国家自然科学基金青年科学基金项目（C类），2027.01-2029.12，主持

代表性论文：（近五年）

1） Jing Hu^#, Xiaoman Ju^#, Biping Deng^#, Kaicheng Tang^#, Dongchen Yuan, Xiaofan Sun, Lingmei Kong, Yixin Xu, Zhuo Fu, Stephane Koda, Simin Shao, Yan Chen, Guowei Sun, Simin Zheng, Hongyu Zhao, Yaqi Liu, Hao Chen, Zilong Zong, Youzhen Ma, Huiping Yu, Yao Qin, Xiaoqing Li, Hui Hua, Yang Zhao, Renxian Tang, Kuiyang Zheng, Chunrong Tong, Michele Woei Ling Teng, Xinrui Dong, Xiaoran Deng, Yan Li^*, Yan-long Yang^*, Yongqiang Chen^*, Juming Yan^*, Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression, Cell Rep Med, 2026, 22:102833. (IF:14.0, 中科院1区Top)

2） Xiaoman Ju^#, Eva Maria Putz^#, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong*, Biping Deng^*, Jing Hu^*, Juming Yan^*, Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation, Nat. Commun, 2025, 16(1): 5874. (IF:18.1 中科院1区Top)

3） Dongchen Yuan^#, Jing Hu^#, Xiaoman Ju^#, Eva Maria Putz, Simin Zheng, Stephane Koda, Guowei Sun, Xiaoran Deng, Zhipeng Xu, Wei Nie, Yang Zhao, Xianyang Li, William C. Dougall, Simin Shao, Yan Chen, Renxian Tang, Kuiyang Zheng^*, Juming Yan^*, NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages, PNAS, 2023, 120(47): e2312019120. (IF:9.5, 中科院1区Top) 

4） Stephane Koda^#, Jing Hu^#, Xiaoman Ju, Guowei Sun, Simin Shao, Ren-Xian Tang, Kuiyang Zheng, Juming Yan^*. The role of glutamate receptors in the regulation of the tumor microenvironment. Front Immunol, 2023, 1(14): 1123841. (IF=5.9，中科院2区)

5） Xiaoman Ju, Dongmei Fan, Lingmei Kong, Qihong Yang, Yiying Zhu, Shaohua Zhang, Guifeng Su, Yan Li^*. Antimicrobial peptide Brevinin-1RL1 from frog skin secretion induces apoptosis and necrosis of tumor cells. Molecules. 2021, 26(7). (IF=5.1，中科院2区)