Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes

By: Quan Fu, Jing Yuan, Tie-Hua Yang, Jin-Hao Su, Jing-Jing Zhang, Xue-Wen Wu, Hong-Ye Zhang, Wei-Lie Xiao, Chang-Bo Zheng, and Xiao-Li Li

Journal of Natural Products

DOI：https://doi.org/10.1021/acs.jnatprod.3c00985

Published：2024-02-03

Abstract

Three nor-sesquiterpenes, phellinharts A-C (1-3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1-3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds 1-3 displayed potent anti-hypertrophic activities with low cytotoxicity (CC50 > 50 mu M) in rat cardiomyocytes, underscoring their therapeutic potential.